Endocrine Abstracts

Background: Several treatment options exist after thyroid malignancy has been ruled out in patients with multinodular goiter (MG). Surgery efficiently reduces the goiter size but carries a risk of both surgical and anesthetic complications while in recent years, levothyroxine suppressive therapy has been abounded. I131 therapy is the only nonsurgical alternative; however, the effectiveness diminishes with increasing goiter size and depends on iodine sufficiency in some areas. ...

A case of a 29-year old woman presented with a 6-year history of bone pain located in the lower spine and gradually extended to the spinal skeleton and the lower extremities, worsening by activity. The progressive symptoms and the established weakness finally led to patient’s complete disability. The investigation revealed low serum phosphorus and elevated 24 h urinary phosphate excretion, normal serum calcium and 24 h urine calcium excretion, normal to normal-high PTH an...

Introduction: The 22q11.2 deletion syndrome (22q11.2DS) caused by a microdeletion of the 22q11.2 region of chromosome 22 is the most common deletion in humans causing a variety of disorders, including DiGeorge syndrome (OMIM #188400), velocardiofacial syndrome (OMIM #192430) and distal chromosome 22q11.2 deletion syndrome (OMIM #611867). Most individuals diagnosed with this condition are identified in early childhood and the diagnosis in adults is uncommon. It is characterized...